Individuals who experience a shingles outbreak are almost twice as likely to develop Chronic Fatigue Syndrome (CFS). Image by: Freedigitalphotos.net

Are you familiar with the herpes virus? That annoying virus that causes cold sores on the lips?

So it turns out that it is not the only Herpes virus, but a member of a family of viruses called herpesviridae.

Therefore there are several types of herpes viruses, while each virus infects a different part of the body, as well as causes different symptoms.

For example, Herpes virus 2 (HSV-2), causes genital warts, whereas Cytomegalovirus (CMV) causes mild symptoms or no symptoms at all [4].

I bet you’re asking yourselves by now, “Why is she telling us all about types of Herpes viruses??”

Well, the fact is that I actually want to tell you about Varicella Zoster Virus (VZV), which is also a member of the Herpesvirus group. Interestingly, primary infections with VZV cause chickenpox whereas shingles is caused by recurrent infection [1].

And it doesn’t end there, after a person recovers from chickenpox, the virus persists in the sensory nerve in a latent state. For reasons that are not fully known, the virus can reactivate years later, causing shingles.

Another interesting fact is that apparently individuals who experience a shingles outbreak are almost twice as likely to develop Chronic Fatigue Syndrome (CFS).

Another interesting fact is that apparently individuals who experience a shingles outbreak are almost twice as likely to develop Chronic Fatigue Syndrome (CFS).

We must realize the fact that many diseases once thought unrelated to each other, emerge as related to a very large extent. Therefore, the importance of continued research in the field is enormous. Image by: www.freedigitalphotos.net

And what is Chronic Fatigue Syndrome you ask? Chronic fatigue syndrome (CFS) is a disorder characterized by unexplainable constant fatigue (tired and weak all the time), while several factors contribute to the development of the disease, such as latent viral infections [2,3].

According to the study, due to its ability to infect the nerves, latent VZV causes long term nerve dysfunction, which helps explain why individuals infected with VZV experience CFS symptoms.

Moreover, additional studies had shown that administering antiherpes agents causes significant improvement in some CFS patients [3].

The medical world is extremely broad, and despite advanced technology and various tools we posses, there are still diseases which are not fully understood.

Furthermore, we must realize the fact that many diseases once thought unrelated to each other, emerge as related to a very large extent. Therefore, the importance of continued research in the field is enormous.

References:

1. CDC.gov – Shingles (Herpes Zoster) – Signs & Symptoms
cdc.gov/shingles/about/symptoms.html

2. Tsai SY1, Yang TY, Chen HJ, Chen CS, Lin WM, Shen WC, Kuo CN, Kao CH. Increased risk of chronic fatigue syndrome following herpes zoster: a population-based study. Eur J Clin Microbiol Infect Dis. 2014 Sep;33(9):1653-9.

3. Shapiro JS. Does varicella-zoster virus infection of the peripheral ganglia cause Chronic Fatigue Syndrome? Med Hypotheses. 2009 Nov;73(5):728-34. ncbi.nlm.nih.gov/pubmed/19520522

4. Whitley, Richard J., David W. Kimberlin, and Bernard Roizman. “Herpes simplex viruses.” Clinical Infectious Diseases (1998): 541-553.